Look at Luke 9:26, notice what is repeated. In the NASB, ashamed and glory. Note what is the object of shame for each use. In the first clause, the object of shame is Christ and His words. In the second clause, the object of shame is the one who held Christ and His words in shame.
That raises some questions. What does it mean to hold Christ in shame; to hold His words in shame. It would seem that if I were to ignore, discount, trivialize, or disobey Christ’s words, that would be tantamount to being ashamed of His word. If I am ashamed of His word, doesn’t it follow that I am ashamed of Him?
Have you ever withdrawn from someone because of something he or she said? Have you ever ignored someone because you did not view them as important or what they said as weighty? Isn’t that what Christ is describing here?
Now consider Matthew 6:33. Christ commands that we seek His kingdom first. If we do not do so, is that being ashamed of His word?
If that is the case is not the effect what Christ describes here?