Is it not true that when we seek to please someone, we are in fact worshipping them? In our relationships, all of them, it would seem that I should not be seeking the favor of the individual, but the favor of the one who created that individual. That would change the way I approach all people. It would put significant shoe leather to Paul’s exhortation in Philippians 2:3 – 11.
Additionally, if my goal is to please God in my dealings with people, to approach them on the basis of serving Him and His goals rather than mine. It seems to me that I would always be successful in relationships. I cannot hope to expect people to respond positively, but I can honor and serve God in the midst of the relationship regardless of how the other person responds.